主要研究论文

1. Xu Long, Yang Yidi, Zhao Mingying, Zhang Hai, Li Sai, Wenxia Gao*, Bin He; Yuji Pu *. A reactive oxygen species–responsive prodrug micelle with efficient cellular uptake and excellent bioavailability,J. Mater. Chem. B,2018,6, 1076-1084.

2. Long Xu, Mingying Zhao, Yidi Yang, Yan Liang, Changzhen Sun, Wenxia Gao*, Sai Li, Bin He, Yuji Pu*. A reactive oxygen species (ROS)-responsive low molecular weight gel co-loaded with doxorubicin and Zn(II) phthalocyanine tetrasulfonic acid for combined chemo-photodynamic therapy,J. Mater. Chem. B,2017,5, 9157-9164.

3. Na Hao ; Changzhen Sun; Zhenfei Wu; Long Xu; ; Jun Cao; Wenxia Gao*, Li Li*; Bin He. Fabrication of Polymeric Micelles with Aggregation-Induced Emission and Forster Resonance Energy Transfer for Anticancer Drug Delivery,Bioconjugate Chemistry,2017, 28, 1944-1954.

4. Taotao Xu ; Junhua Li; Jun Cao; Wenxia Gao*; Li Li* ; Bin He. The effect of α-cyclodextrin on poly(pseudo)rotaxane nanoparticles self-assembled by protoporphyrin modified poly(ethylene glycol) for anticancer drug delivery,Carbohydrate Polymers,2017, 174, 789-797.

5. Ning Tao ; Guotao Li; Miaochang Liu; Wenxia Gao*; Huayue Wu* . Preparation of dual responsive low-molecular-weight hydrogel for long-lasting drug delivery,Tetrahedron,2017, 73, 3173-3180.

6. Yan Liang, Wenxia Gao*, Xinyu Peng, Xin Deng, Changzhen Sun, Huayue Wu, Bin He*.Near infrared light responsive hybrid nanoparticles for synergistic therapy.Biomaterials,2016, 100,76-90.

7. Wenxia Gao, Yan Liang*, Xinyu Peng, Yalong Hu, Longgui Zhang, Huayue Wu, Bin He*.In situ injection of phenylboronic acid based low molecular weight gels for efficient chemotherapy.Biomaterials,2016, 105,1-11.

8. Yalong Hu, Wenxia Gao*, Fang Wu, Huayue Wu, Bin He, Jing He*. Low molecular weight gels induced differentiations of mesenchymal stem cells.J. Mater. Chem. B,2016,4, 3504-3508.

9. Long Xu, Yalong Hu, Miaochang Liu, Jiuxi Chen, Xiaobo Huang, Wenxia Gao*, Huayue Wu*. Gelation properties and glucose-sensitive behavior of phenylboronic acid based low-molecular-weight organogels.Tetrahedron,2015,71, 2079-2088.

10. Kaiwen Yang, Sicheng Wan, Binbin Chen, Wenxia Gao*, Jiuxi Chen, Miaochang Liu, Huayue Wu*. Dual pH and temperature responsive hydrogels basedβ-cyclodextrin derivatives for atorvastatin delivery.Carbohy. Polym.,2015,136, 300-306.

11. Chaoyu Zhou, Wenxia Gao*, Kaiwen Yang, Long Xu, Jiuxi Chen, Miaochang Liu, Xiaobo Huang, Huayue Wu*. A novel glucose/pH responsive low-molecular-weight organogel of easy recycling.Langmuir,2013,29, 13568-13575.

12. Chaoyu Zhou, Wenxia Gao*, Guangming Lu, Xiuming Wu, Xiaobo Huang, Jiuxi Chen, Huayue Wu*. Preparation, characterization and in vitro release of microparticles based on dextran-rosuvastatin conjugate.Carbohy. Polym.,2013,96, 156-162.

13. Xiepeng Lin, Wenxia Gao*, Chenen Li, Jiuxi Chen, Chen Yang, Huayue Wu*. Nano-sized flake carboxymethyl cassava starch as excipient for solid dispersions.Int. J. Pharmaceut.,2012,423, 435-439.

14. Wenxia Gao,Xiaoqing Lin, Xiepeng Lin, Jinchang Ding, Xiaobo Huang, Huayue Wu*. Preparation of nano-sized flake carboxymethyl cassava starch under ultrasonic irradiation.Carbohy. Polym.,2011,84, 1413-1418.

15. Xiepeng Lin, Wenxia Gao*, Xiaobo Huang, Panlong Zang, Jiuxi Chen, Huayue Wu*. Morphology-controlled hollow nanospheres of functionalized dextran by self-assembly in aqueous solution.Carbohy. Polym.,2010,82, 460-465.

主要科研项目

1. 国家自然科学基金面上项目，21672164，近红外光多点触发高灵敏刺激响应的功能分子设计、合成及载药系统研究，2017.01.01-2020.12.31，65万元，在研，主持

2. 温州市科技局项目，Y20170162，高效抗非小细胞肺癌双硫仑-高分子胶束纳米药物研究，2017.07.01-2019.12.31，2万元，在研，主持

3. 浙江省自然科学基金，LY15B020001，基于有机小分子凝胶非共价方式“门控”的智能介孔骨架型药物载体的构建及性能研究，2015.01.01-2017.12.31，8万元，已结题，主持

4. 国家自然科学基金青年基金，21202122，葡萄糖快速响应型有机小分子凝胶的设计、合成及性能研究，2013.01.01-2015.12.31，25万元，已结题，主持

5. 浙江省科技厅公益项目，2013C33188，有机硼酸小分子凝胶类胰岛素控释材料的设计合成与应用开发研究，2013.01.01-2014.12.31，10万元，已结题，主持

6. 温州市科技局项目，G20090079，5-氨基-2-氯-N-(2,4-二甲苯基)-苯磺酰胺清洁生产工艺开发，2009-2011，10万元，已结题，主持

授权专利

1. 高文霞,吴华悦,周超宇,陈久喜,刘妙昌,黄小波,蒋俊,万思成。一种苯硼酸类有机凝胶化合物, ZL201210375089.0.

2. 高文霞,徐龙,吴华悦,陈久喜,刘妙昌,黄小波,蒋俊。一类苯硼酸类有机凝胶化合物, ZL201310361889.1.

3. 高文霞,吴华悦,万思成,陈久喜,刘妙昌,黄小波,陈彬彬,杨凯文。一种环境敏感型环糊精衍生物水凝胶的制备方法, ZL201410504485.8.

4. 吴华悦;高文霞;刘妙昌;陈久喜;韩丹丹;狄安利;池艳艳;金杰,一种杀扑磷纳米乳剂及其制备方法, ZL201210376780.0

5. 高文霞;吴华悦;陈久喜;刘妙昌;林勰鹏;杨臣,一种纳米级片状羧甲基淀粉钠在固体分散体中的应用, ZL 201110339510.8

6. 高文霞;吴华悦;李晨恩;刘妙昌;陈久喜,一种氯氰菊酯水乳剂及其制备方法, ZL 201110331083.9

7. 吴华悦;高文霞;刘妙昌;陈久喜;周超宇;卢广敏,一种瑞舒伐他汀-右旋糖酐酯的制备方法, ZL 201110329343.9

8. 高文霞;吴华悦;陈久喜;刘妙昌;林勰鹏,一种纳米级片状羧甲基淀粉钠的制备方法, ZL 201110009231.5

主要获奖情况

2015，浙江省151人才第三层次

2014，温州市551人才第二层次

2012，温州市551人才第三层次

2012，第十四届温州市自然科学优秀论文奖

2010，浙江省第六届青年教师教学技能奖